Simulation Process

Simulation Process (detailed steps)

Assess the risk of drug interactions in just a few simple steps.

1. STEP1

   Import parameter fitting results (edit pharmacokinetic parameters)

   Import results of the parameter fitting tool as well as edit registered pharmacokinetic parameter values.

2. STEP2

   Select a model

   Select from any of the three available models.

   1Enzyme Inhibition/Induction Model

   A model for predicting drug interactions via metabolic enzyme inhibition and/or induction.

   

   2Transporter Inhibition Model

   A model for predicting drug interactions via transporter inhibition

   

   3Hepatic OATPs Inhibition Model

   A model for predicting drug interactions via OATPs in the liver.

   

3. STEP3

   Choose drug combinations

   Choose from the available list of 52 substrates, 35 inhibitors and 1 inducer.

4. STEP4

   Specify dosing regimen

   Setting Options

   • Dosage
   • Dosing Frequency
   • Dosing Interval
   • Substrate Dose Timing

5. STEP5

   Run simulation

   In the case of metabolic enzyme inhibition/induction models, evaluation by cutoff criteria (Basic model) and static drug kinetics (MSPK) models are also possible.

6. STEP6

   Display results

   • Display the plasma concentration-time curve in each organ.
   • Display a list of simulation results.
   • Export simulation results to CSV file.