ADME Database provides the latest and most comprehensive data on interactions of substances with Drug Metabolizing Enzymes and Drug Transporters that are specific to humans. It is designed for use in drug research and development, including drug-drug interactions and ADME(Absorption, Distribution, Metabolism and Excretion) studies. The contents of the database were collected and organized in accordance with the original Human P450 and Transporter Metabolism Database as developed by Professor Slobodan Rendic (Zagreb, Croatia).
Human Drug Metabolizing Enzyme Database
- Contains information on CYP enzymes and a number of variants, which participate/are tested in the metabolism of xenobiotics and endobiotics in humans.
- Contains information on substances (as well as a number of natural products and other factors) influencing CYP activity based on the following type of interactions:
- Contains information on the following enzymes:
- Glutathione S-transferases
- Flavin-containing Monooxygenases
|Kinetics Information Database(1)
- Contains supporting entries for the Human Drug Metabolizing Enzyme Database, providing numerical data on major kinetic parameters relevant for use in drug development/application studies.
- in vitro assay used
- (1) Kinetic Database is available only when it is coupled with Human Drug Metabolizing Enzyme Database.
Human Drug Transporter Database
- Contains information on transporters involved in transport of drugs, physiological compounds, nutrients, and other chemicals and metabolites.
- ABC Transporters
- Organic Ion Transporters
- Peptide Transporters
- Nucleotide Transporters
Number of Entries
||Drug Metabolizing Enzymes
Data as of April 2019
Data will be updated quarterly.